To assess which antiepileptic medications (AEDs) he the best evidence for long-term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or untreated epilepsy.A 10-member subcommission of the Commission on Therapeutic Strategies of The International League Against Epilepsy (ILAE), including and pediatric epileptologists, clinical pharmacologists, clinical trialists, and a statistician evaluated ailable evidence found through a structured literature review including MEDLINE, Current Contents and the Cochrane Library for all applicable articles from 1940 until July 2005. Articles dealing with different seizure types (for different age groups) and two epilepsy syndromes were assessed for quality of evidence (four classes) based on predefined criteria. Criteria for class I classification were a double-blind randomized controlled trial (RCT) design, ≥48-week treatment duration without forced exit criteria, information on ≥24-week seizure freedom data (efficacy) or ≥48-week retention data (effectiveness), demonstration of superiority or 80% power to detect a ≤20% relative difference in efficacy/effectiveness versus an adequate comparator, and appropriate statistical ysis. Class II studies met all class I criteria except for hing either treatment duration of 24 to 47 weeks or, for noninferiority ysis, a power to only exclude a 21–30% relative difference. Class III studies included other randomized double-blind and open-label trials, and class IV included other forms of evidence (e.g., expert opinion, case reports). Quality of clinical trial evidence was used to determine the strength of the level of recommendation.
核对信源定址
编辑: jiang上一页:临床如何诊断前提患有轻度癫痫
- 2022-05-05不开颅微创”黑科技“,激光间质热疗LITT技术8问8询
- 2022-05-02Rheumatol Int:儿童慢性非细菌性骨髓炎:多中心病症系列报道
- 2022-04-13大一男生差点失去蛋蛋!医生提醒,天气很冷,年轻男性不应该使用这些取暖神器
- 2022-04-12Sci Rep:成人睾丸中内源性素系统成分的特征和定位
- 2022-04-07癫痫患者手术评估新型工具
- 2022-04-06奥硝唑、甲硝唑和替硝唑有什么区别?
- 大一男生差点失去蛋蛋!医生提醒,天气很冷,年轻男性不应该使用这些取暖神器
- Sci Rep:成人睾丸中内源性素系统成分的特征和定位
- 有什么禁忌吗?
- 癫痫患者手术评估新型工具
- 奥硝唑、甲硝唑和替硝唑有什么区别?
- 为什么光疗能有效治疗白癜风?
- 2013国际抗癫痫联合会抗癫痫药用指南
- 如何治疗附睾囊肿?医生介绍了治疗方法!
- Autoimmun Rev:心肌炎是一种系统性免疫介导性疾病:发病率、特征和预后
- 癫痫发作对中风患者静脉溶栓的长期转移有效
- Medicine:首次对育龄妇女桥本甲状腺炎进行大规模试验
- 肿痛的原因是什么?这五个时期需要多加注意!
- 治疗类风湿性关节炎/膝骨关节炎的专家共识
- 天麻有什么功效 天麻的五个好处让你不满意
- 治疗脑炎后遗症的方法有哪些?
- 抗癫痫药物预防新发癫痫:任重而道远
- 流产对女性的伤害太大了
- 都说多吃豆腐少吃肉。豆腐有什么营养价值?
- 成人羊角风病的病因是什么?
- 白癜风防治指南:记住这六点,对你的病情有帮助!
- Neurology:颅脑损伤增加了迟发性癫痫的风险,高损伤频率、重伤、老年人尤其是
- 癫痫的检查诊断方法有哪些 癫痫的检查费用高?
- 宫颈糜烂的原因 多次流产会引起这种疾病(2)
- 女性月经保健 如何避免月经期间对身体的伤害?
- 钙化是怎么回事?
- 精神分裂症患者必须终生与药为伍吗?一文讲清
- 洋甘菊精油的沐浴法 洋甘菊精油能预防气喘
- 国医养生堂:吴全兴讲如何预防儿童癫痫
- JAMA Neurology:左乙拉西坦对伴有与不伴有癫痫样活动的阿尔茨海默病患者认知系统的影响
- 兴癫痫病能兴的好么
- 导致癫痫经常发作的病因是什么
- 不伴小脑内侧硬化的小脑癫痫患者隔核增大
- 脑梗的症状有哪些 有了这些前兆要小心谨慎
- 男婴癫痫病怎么治疗
- 磨牙是怎么回事 如何有效性预防磨牙
- 乙肝的传染除此以外 6种除此以外成乙肝传染重灾区(2)
- 普瑞巴林单药治疗部分性癫痫发作安全有效地
- 癫痫病肇因的主要病因是啥
- 运用于抗癫痫药物的患者,能用抗病吗?
- 怎么治疗不良少年稳定型癫痫病比较好